Monitoring of Minimal Residual Disease and Mixed Chimerism in a Case of High-risk Tel/aml1-positive Acute Lymphocytic Leukemia
نویسندگان
چکیده
therapy (methotrexate, idarubicin) but we observed hematologic relapse after three months of CR; FISH analysis showed the same chromosomal abnormality. Reinduction therapy was started with the FLANG regimen. The girl died of resistant disease in December 1999. Several groups have reported a higher incidence of abnormal/complex karyotypes in AMLM0, particularly deletion -7/7q and/or -5/5q and trisomy 8, 4 and 13, which are all frequently associated with poor prognosis.1,6 To our knowledge, this t(8;13;14) is the first described in the literature.7 In this three-way translocation between chromosomes 8, 13 and 14 we also analyzed whether the regions of chromosomes 8 and 14 involved were the same as those found in the t(8;14) reciprocal translocation commonly associated with ALL L3.8,9 Our data showed that C-MYC was not involved in the rearrangement (data not shown). Larger studies are needed to clarify which chromosome abnormalities contribute to the poor prognosis of this disease.
منابع مشابه
The relation between end of induction minimal residual disease and different risk factors in patients with acute lymphoblastic leukemia
Background: Malignant disorder with B or T stem cell basis leads to development and continuation of acute lymphoblastic leukemia (ALL) due to aggregation of blast cells in bone marrow. The environmental, genetic, and demographic factors may influence the disease relapse. The objective of this study was to assess the relation between end of induction minimal residual disease and different risk f...
متن کاملClinical, Morphological and Immunophenotypical Findings in Acute Leukemia: A Study from a Tertiary Care Hospital
Background: Acute leukemias comprise a heterogeneous group of diseases characterized by rapid and uncontrolled clonal expansion of progenitor cells of the hematopoietic system. Immunophenotyping helps subclassify acute leukemias into subgroups with prognostic implications. Materials and Methods: This descriptive observational cross-sectional study was performed on 80 newly diagnosed cases of a...
متن کاملEvaluation of Relationship between Minimal Residual Disease (MRD) and Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) Using Quantitative Fluorescent PCR
متن کامل
Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study
OBJECTIVES We have analyzed t(12;21)(p13:q22) in an attempt to evaluate the frequency and prognostic significance of TEL-AML1 fusion gene in patients with childhood CD 10 positive B-ALL by fluorescence in situ hybridization (FISH). Also, we have monitored the prognostic value of this gene as a minimal residual disease (MRD). METHODS All bone marrow samples of eighty patients diagnosed as CD 1...
متن کاملAsparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia.
Resistance to L-asparaginase in leukemic cells may be caused by an elevated cellular expression of asparagine synthetase (AS). Previously, we reported that high AS expression did not correlate to L-asparaginase resistance in TEL-AML1-positive B-lineage acute lymphoblastic leukemia (ALL). In the present study we confirmed this finding in TEL-AML1-positive patients (n = 28) using microarrays. In ...
متن کامل